A teratologic suppressor role for p53 in benzo[a]pyrene-treated transgenic p53-deficient mice.

doi:10.1038/ng0695-181

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Article

A teratologic suppressor role for p53 in benzo[a]pyrene-treated transgenic p53-deficient mice.

Nature genetics - 1 Jun 1995

Nicol C J, Harrison M L, Laposa R R, Gimelshtein I L, Wells P G

Abstract excerpt

DNA damage may mediate birth defects caused by many drugs and environmental chemicals, therefore p53, a tumour suppressor gene that facilitates DNA repair, may be critically embryoprotective. We have studied the effects of the environmental teratogen, benzo[a]pyrene, on pregnant heterozygous p53-deficient mice. Such mice exhibited between 2- to 4-fold higher embryotoxicity and teratogenicity than normal...

Topics

Abnormalities, Drug-Induced
Animals
Base Sequence
Benzo(a)pyrene
Cytochrome P-450 Enzyme System
Enzyme Induction
Female
Fetal Resorption
Gene Deletion
Genes, p53
Genotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Male

Mice

Mice, Inbred C57BL

Mice, Transgenic

Models, Biological

Molecular Sequence Data

Polychlorinated Dibenzodioxins

Source

Open in PubMed

Identifiers

PMID: 7663513
DOI: 10.1038/ng0695-181

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7663513-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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