Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Ovarian effects of prenatal exposure to benzo[a]pyrene: Roles of embryonic and maternal glutathione status.

Reproductive toxicology (Elmsford, N.Y.) - 1 Apr 2017

Luderer Ulrike, Myers Meagan B, Banda Malathi, McKim Karen L, Ortiz Laura, Parsons Barbara L

Abstract excerpt

Females deficient in the glutamate cysteine ligase modifier subunit (Gclm) of the rate-limiting enzyme in glutathione synthesis are more sensitive to ovarian follicle depletion and tumorigenesisby prenatal benzo[a]pyrene (BaP) exposure than Gclm+/+ mice. We investigated effects of prenatal exposure to BaP on reproductive development and ovarian mutations in Kras, a commonly mutated gene in epithelial ovarian...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Benzo(a)pyrene
Share to Glutamate-Cysteine Ligase

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Glutathione

Share to Maternal-Fetal Exchange

Share to Mice, Mutant Strains

Share to Prenatal Exposure Delayed Effects

Share to Sexual Maturation

Source

Open in PubMed Open full text

Identifiers

PMID: 28279692
DOI: 10.1016/j.reprotox.2017.03.001
PMCID: PMC5422106

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Ovarian effects of prenatal exposure to benzo[a]pyrene: Roles of embryonic and maternal glutathione status.PMID 28279692Read ↗

Maternal pre-conceptional glyphosate exposure impacts the offspring hepatic and ovarian proteomeSemantic proximity Read ↗

Paternal Exposure to Environmental Chemical Stress Affects Male Offspring’s Hepatic MitochondriaSemantic proximity Read ↗

The behavioral effects of gestational and lactational benzo[a]pyrene exposure vary by sex and genotype in mice with differences at the <i>Ahr</i> and <i>Cyp1a2</i> lociSemantic proximity Read ↗

In Utero Exposure to Benzo[a]Pyrene Increases Mutation Burden in the Soma and Sperm of Adult Mice.Semantic proximity Read ↗

The behavioral effects of gestational and lactational benzo[a]pyrene exposure vary by sex and genotype in mice with differences at the Ahr and Cyp1a2 loci.Semantic proximity Read ↗

Antioxidant supplementation partially rescues accelerated ovarian follicle loss, but not oocyte quality, of glutathione-deficient mice†.Semantic proximity Read ↗

Induction of proapoptotic gene expression and recruitment of p53 herald ovarian follicle loss caused by polycyclic aromatic hydrocarbons.Semantic proximity Read ↗

Attenuated expression of MTR in both prenatally androgenized mice and women with the hyperandrogenic phenotype of PCOS.Semantic proximity Read ↗

Paternal B Vitamin Intake Is a Determinant of Growth, Hepatic Lipid Metabolism and Intestinal Tumor Volume in Female Apc1638N Mouse Offspring.Semantic proximity Read ↗

Prenatal exposure of mice to the human liver carcinogen aflatoxin B1 reveals a critical window of susceptibility to genetic change.Semantic proximity Read ↗

Embryonic prostaglandin H synthase-2 (PHS-2) expression and benzo[a]pyrene teratogenicity in PHS-2 knockout mice.Semantic proximity Read ↗

Effects of deletion of the transcription factor Nrf2 and benzo [a]pyrene treatment on ovarian follicles and ovarian surface epithelial cells in mice.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.