Article
Analysis of the genotypes for aldehyde dehydrogenase 2 in Japanese patients with primary gout.
Advances in experimental medicine and biology - 1 Jan 1994
Yamanaka H, Kamatani N, Hakoda M, Terai C, Kawaguchi R, Kashiwazaki S
Abstract excerpt
Alcoholic ingestion is one of the major factors for increasing serum uric acid levels. Genotypes of aldehyde dehydrogenase 2 (ALDH2, E.C.1.2.1.3), which regulates the sensitivity of an individual to ethanol, were determined in Japanese patients with gout and control subjects by allele specific oligonucleotide hybridization using PCR amplified gene. The most common allele ALDH2*1 codes for normal ALDH2 activity,...
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