Independent effects of ADH1B and ALDH2 common dysfunctional variants on gout risk.

doi:10.1038/s41598-017-02528-z

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Article

Independent effects of ADH1B and ALDH2 common dysfunctional variants on gout risk.

Scientific reports - 31 May 2017

Sakiyama Masayuki, Matsuo Hirotaka, Akashi Airi, Shimizu Seiko, Higashino Toshihide, Kawaguchi Makoto, Nakayama Akiyoshi, Naito Mariko, Kawai Sayo, Nakashima Hiroshi, Sakurai Yutaka, Ichida Kimiyoshi, Shimizu Toru, Ooyama Hiroshi, Shinomiya Nariyoshi

Abstract excerpt

Gout is caused by hyperuricemia, with alcohol consumption being an established risk factor. Alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) are crucial enzymes for alcohol metabolism. We recently performed a genome-wide association study of gout and a subsequent fine-mapping study which identified rs671 of ALDH2 as a gout locus. However, the association between gout and common variants of ADH1B has...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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PMID: 28566767
DOI: 10.1038/s41598-017-02528-z
PMCID: PMC5451470

Genes

ALDH2

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Independent effects of ADH1B and ALDH2 common dysfunctional variants on gout risk.PMID 28566767Read ↗

Risk of gout among Taiwanese adults with ALDH-2 rs671 polymorphism according to BMI and alcohol intake.Semantic proximity Read ↗

Identification of rs671, a common variant of ALDH2, as a gout susceptibility locus.Semantic proximity Read ↗

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Common dysfunctional variants in ABCG2 are a major cause of early-onset goutSemantic proximity Read ↗

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Common dysfunctional variants of ABCG2 have stronger impact on hyperuricemia progression than typical environmental risk factors.Semantic proximity Read ↗

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