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Article

Increased DNA damage in ALDH2-deficient alcoholics.

Chemical research in toxicology - 1 Oct 2006

Matsuda Tomonari, Yabushita Hisatoshi, Kanaly Robert A, Shibutani Shinya, Yokoyama Akira

Abstract excerpt

Drinking alcohol is a risk factor for cancers of the oral cavity, pharynx, larynx, and esophagus. Although many studies suggest that acetaldehyde, a major metabolite of orally ingested alcohol, plays a crucial role in cancer initiation, the link between the aldehyde dehydrogenase-2 (ALDH2) genotype and acetaldehyde-derived DNA damage has not yet been explored. We have developed a sensitive and quantitative method...

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Source

Identifiers

PMID: 17040107
DOI: 10.1021/tx060113h

Genes

ALDH2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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