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Article

Disruption of the gene encoding SF-1 alters the distribution of hypothalamic neuronal phenotypes.

The Journal of comparative neurology - 7 Aug 2000

Dellovade T L, Young M, Ross E P, Henderson R, Caron K, Parker K, Tobet S A

Abstract excerpt

The ventromedial nucleus of the hypothalamus (VMH) in mice first emerges as a histologically distinct cell cluster around embryonic day 17 (E17). The earliest known marker for cells destined to form the VMH is the orphan nuclear receptor, steroidogenic factor 1 (SF-1), which can be detected in the hypothalamic primordium by E11. Strikingly, the VMH is absent in newborn SF-1 knockout mice, suggesting that SF-1 is...

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PMID: 10880989
DOI: 10.1002/1096-9861(20000807)423:4<579::aid-cne4>3.0.co;2-#

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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