A human papillomavirus type 18 E6/E7 transgene sensitizes mouse lens cells to human wild-type p53-mediated apoptosis.

doi:10.1038/sj.onc.1201155

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Article

A human papillomavirus type 18 E6/E7 transgene sensitizes mouse lens cells to human wild-type p53-mediated apoptosis.

Oncogene - 26 Jun 1997

Nakamura T, Williams-Simons L, Westphal H

Abstract excerpt

We have studied the concerted action of factors that influence the balance between cell proliferation and cell death in the developing lens of transgenic mice. We show that a human papillomavirus type 18 (HPV18) E6/E7 transgene that predominantly expresses the viral E7 gene product triggers apopt...

Topics

Animals
Apoptosis
DNA-Binding Proteins
Genes, p53
Humans
Lens, Crystalline
Mice
Mice, Transgenic
Mutation
Oncogene Proteins, Viral
Phenotype
Retinoblastoma Protein
Transgenes

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