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Article

Role of the executioner caspases during lens development.

The Journal of biological chemistry - 26 Aug 2005

Zandy Anna J, Lakhani Saquib, Zheng Timothy, Flavell Richard A, Bassnett Steven

Abstract excerpt

The notion that the cell death machinery is utilized during lens organelle degradation is supported by the observation that well characterized apoptotic substrates are cleaved during this process. Here, we test directly the role of executioner caspases (caspase-3, -6, and -7) in fiber cell differentiation. The distribution of mRNA, protein, and enzymatic activity for each caspase was determined in the mouse lens....

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Source

Identifiers

PMID: 15994297
DOI: 10.1074/jbc.M504007200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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