Article
An apoptotic defect in lens differentiation caused by human p53 is rescued by a mutant allele.
Proceedings of the National Academy of Sciences of the United States of America - 20 Jun 1995
Nakamura T, Pichel J G, Williams-Simons L, Westphal H
Abstract excerpt
If deprived of wild-type p53 function, the body loses a guardian that protects against cancer. Restoration of p53 function has, therefore, been proposed as a means of counteracting oncogenesis. This concept of therapy requires prior knowledge with regard to proper balance of p53 function in a given target tissue. We have addressed this problem by targeting expression of the wild-type human p53 gene to the lens, a...
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