Article
An apoptotic defect in lens differentiation caused by human p53 is rescued by a mutant allele.
Proceedings of the National Academy of Sciences of the United States of America - 20 Jun 1995
Nakamura T, Pichel J G, Williams-Simons L, Westphal H
Abstract excerpt
If deprived of wild-type p53 function, the body loses a guardian that protects against cancer. Restoration of p53 function has, therefore, been proposed as a means of counteracting oncogenesis. This concept of therapy requires prior knowledge with regard to proper balance of p53 function in a giv...
Topics
- Aging
- Alanine
- Alleles
- Animals
- Apoptosis
- Arginine
- Cell Differentiation
- Codon
- Epithelial Cells
- Gene Expression
- Genes, p53
- Genetic Therapy
- Humans
- Lens, Crystalline
- Mice
- Mice, Transgenic
- Microphthalmos
- Point Mutation