Article
Bone morphogenetic protein-4 is required for mesoderm formation and patterning in the mouse.
Genes & development - 1 Sept 1995
Winnier G, Blessing M, Labosky P A, Hogan B L
Abstract excerpt
Bone morphogenetic protein-4 (BMP-4) is a member of the TGF-beta superfamily of polypeptide signaling molecules, closely related to BMP-2 and to Drosophila decapentaplegic (DPP). To elucidate the role of BMP-4 in mouse development the gene has been inactivated by homologous recombination in ES ce...
Topics
- Animals
- Base Sequence
- Bone Morphogenetic Proteins
- Cell Line
- Chimera
- Crosses, Genetic
- Embryonic and Fetal Development
- Female
- Gastrula
- Gene Targeting
- Heterozygote
- Homozygote
- Male
- Mesoderm
- Mice
- Mice, Inbred C57BL
- Molecular Sequence Data
- Phenotype