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Article

Bmp2 and Bmp4 genetically interact to support multiple aspects of mouse development including functional heart development.

Genesis (New York, N.Y. : 2000) - 1 Jun 2009

Uchimura Takashi, Komatsu Yoshihiro, Tanaka Momo, McCann Kelly L, Mishina Yuji

Abstract excerpt

Bone morphogenetic proteins (BMPs) have multiple roles during embryogenesis. Current data indicate that the dosage of BMPs is tightly regulated for normal development in mice. Since Bmp2 or Bmp4 homozygous mutant mice show early embryonic lethality, we generated compound heterozygous mice for Bmp2 and Bmp4 to explore the impact of lowered dosage of these BMP ligands. Genotyping pups bred between Bmp2 and Bmp4...

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Share to Bone Morphogenetic Protein 2
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19391114
DOI: 10.1002/dvg.20511
PMCID: PMC2847484

Genes

BMP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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