Article
Disease-associated autoantibodies and HLA-DQB1 genotypes in children with newly diagnosed insulin-dependent diabetes mellitus (IDDM). The Childhood Diabetes in Finland Study Group.
Clinical and experimental immunology - 1 Apr 1999
Sabbah E, Savola K, Kulmala P, Reijonen H, Veijola R, Vähäsalo P, Karjalainen J, Ilonen J, Akerblom H K, Knip M
Abstract excerpt
The possible relation between HLA-DQ genotypes and both frequencies and levels of autoantibodies associated with IDDM was assessed by examining HLA-DQB1 alleles and antibodies to islet cells (ICA), insulin (IAA), glutamic acid decarboxylase (GADA) and the protein tyrosine phosphatase-related IA-2 molecule (IA-2A) in 631 newly diagnosed diabetic children under the age of 15 years. ICA were found in 530 children...
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