Islet cell autoimmunity and progression to insulin-dependent diabetes mellitus in genetically high- and low-risk siblings of diabetic children. The Childhood Diabetes in Finland (DiMe) Study Group.

doi:10.1111/j.1365-2362.1996.tb02147.x

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Article

Islet cell autoimmunity and progression to insulin-dependent diabetes mellitus in genetically high- and low-risk siblings of diabetic children. The Childhood Diabetes in Finland (DiMe) Study Group.

European journal of clinical investigation - 1 Aug 1996

Karjalainen J, Vähasalo P, Knip M, Tuomilehto-Wolf E, Virtala E, Akerblom H K

Abstract excerpt

Insulin-dependent diabetes mellitus (IDDM) risk was evaluated in 765 siblings based on prospective observation of islet cell antibodies (ICAs) and insulin autoantibodies (IAAs) as a function of the degree of HLA identity to the proband and HLA-DR alleles. Twenty-eight (3.7%) siblings progressed t...

Topics

Actuarial Analysis
Adolescent
Alleles
Autoimmunity
Biomarkers
Child
Child, Preschool
Diabetes Mellitus, Type 1
Female
Finland
HLA Antigens
Haplotypes
Humans
Infant
Insulin

Source

Open in PubMed

Identifiers

PMID: 8872058
DOI: 10.1111/j.1365-2362.1996.tb02147.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8872058-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Islets of Langerhans

Male

Risk Factors