Article
HLA-DQB1-defined genetic susceptibility, beta cell autoimmunity, and metabolic characteristics in familial and nonfamilial insulin-dependent diabetes mellitus. Childhood Diabetes in Finland (DiMe) Study Group.
The Journal of clinical investigation - 1 Dec 1996
Veijola R, Reijonen H, Vähäsalo P, Sabbah E, Kulmala P, Ilonen J, Akerblom H K, Knip M
Abstract excerpt
Familial aggregation of insulin-dependent diabetes mellitus (IDDM) is a common phenomenon, but the reasons behind it are poorly understood. To investigate whether there is heterogeneity between familial and nonfamilial forms of IDDM we compared genetic, immunological, and clinical characteristics...
Topics
- Adolescent
- Autoantibodies
- Child
- Diabetes Mellitus, Type 1
- Disease Susceptibility
- Family
- Female
- Finland
- Follow-Up Studies
- Genetic Predisposition to Disease
- Genotype
- Glutamate Decarboxylase
- HLA-DQ Antigens
- HLA-DQ beta-Chains