Article
G protein mutations in endocrine diseases.
European journal of endocrinology - 1 Nov 2001
Lania A, Mantovani G, Spada A
Abstract excerpt
This review summarizes the pathogenetic role of naturally occurring mutations of G protein genes in endocrine diseases. Although in vitro mutagenesis and transfection assays indicate that several G proteins have mitogenic potential, to date only two G proteins have been identified which harbor naturally occurring mutations, Gsalpha, the activator of adenylyl cyclase and Gi2alpha, which is involved in several...
Topics
- Animals
- Endocrine System Diseases
- GTP-Binding Proteins
- Humans
- Mutation
