p21/WAF1, p53 and PCNA expression and p53 mutation status in hepatocellular carcinoma.

doi:10.1002/(sici)1097-0215(19980821)79:4<424::aid-ijc19>3.0.co;2-4

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Article

p21/WAF1, p53 and PCNA expression and p53 mutation status in hepatocellular carcinoma.

International journal of cancer - 21 Aug 1998

Qin L F, Ng I O, Fan S T, Ng M

Abstract excerpt

The cyclin-dependent kinase inhibitor p21/WAF1 is regulated by p5S3-dependent and p53-independent pathways. In addition, p21/WAF1 binds with proliferating cell nuclear antigen (PCNA) and inhibits the action of PCNA. To investigate the possible role of p21/WAF1 in human hepatocellular carcinomas (...

Topics

Adult
Aged
Carcinoma, Hepatocellular
Cyclin-Dependent Kinase Inhibitor p21
Cyclins
Female
Genes, p53
Humans
Immunohistochemistry
Liver Neoplasms
Male
Middle Aged
Mutation
Proliferating Cell Nuclear Antigen
Tumor Suppressor Protein p53

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