Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Biotransformation and pharmacokinetics of ethylmorphine after a single oral dose.

British journal of clinical pharmacology - 1 Jun 1995

Aasmundstad T A, Xu B Q, Johansson I, Ripel A, Bjørneboe A, Christophersen A S, Bodd E, Mørland J

Abstract excerpt

1. The pharmacokinetics of ethylmorphine after administration of a single dose of the cough mixture Cosylan were investigated in 10 healthy subjects. 2. The median urinary recovery of ethylmorphine and measured metabolites was 77% over 48 h. The median tmax of unchanged ethylmorphine was 45 min, and the terminal elimination t1/2 was 2 h. Ethylmorphine-6-glucuronide was found to be the major metabolite. 3. Two...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biotransformation
Share to Cytochrome P-450 Enzyme System

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Drug Administration Schedule

Share to Genotype

Share to Glucuronates

Share to Morphine

Source

Open in PubMed Open full text

Identifiers

PMID: 7654478
DOI: 10.1111/j.1365-2125.1995.tb05720.x
PMCID: PMC1365072

Genes

MRO

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Biotransformation and pharmacokinetics of ethylmorphine after a single oral dose.PMID 7654478Read ↗

Dihydrocodeine: a new opioid substrate for the polymorphic CYP2D6 in humans.Semantic proximity Read ↗

Urinary excretion of codeine, ethylmorphine, and their metabolites: relation to the CYP2D6 activity.Semantic proximity Read ↗

Endogenous codeine and morphine in poor and extensive metabolisers of the CYP2D6 (debrisoquine/sparteine) polymorphism.Semantic proximity Read ↗

Death of a 10-month-old boy after exposure to ethylmorphine.Semantic proximity Read ↗

Exploration of the metabolism of dihydrocodeine via determination of its metabolites in human urine using micellar electrokinetic capillary chromatography.Semantic proximity Read ↗

CYP2D6 phenotype determines the metabolic conversion of hydrocodone to hydromorphone.Semantic proximity Read ↗

O-demethylation of codeine to morphine inhibited by low-dose levomepromazine.Semantic proximity Read ↗

Same incidence of adverse drug events after codeine administration irrespective of the genetically determined differences in morphine formation.Semantic proximity Read ↗

Pharmacokinetics of codeine and its metabolites in Caucasian healthy volunteers: comparisons between extensive and poor hydroxylators of debrisoquine.Semantic proximity Read ↗

Fatal and severe codeine intoxication in 3-year-old twins--interpretation of drug and metabolite concentrations.Semantic proximity Read ↗

The role of active metabolites in dihydrocodeine effects.Semantic proximity Read ↗

The influence of carboxylesterase 1 polymorphism and cannabidiol on the hepatic metabolism of heroin.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.