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Article

Resistance to cytosine arabinoside in cells transfected with activated Ha-ras oncogene.

Anticancer research - 1 Jan 2000

Riva C, el Khyari S, Rustum Y, Barra Y

Abstract excerpt

The molecular basis for cancer cell resistance to 1-beta-D-arabinofuranosylcytosine (ara-C) is not well understood. Since aberrant expression and mutations of various ras oncogenes have been implicated in the poor prognosis of human cancers and in several mechanisms of drug resistance, we tested...

Topics

Animals
Base Sequence
Cells, Cultured
Cytarabine
Drug Resistance
Gene Expression Regulation
Genes, ras
Humans
Molecular Sequence Data
Mutation
Rats
Rats, Inbred F344
Transfection

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PMID: 7654012

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7654012-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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