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Article

Resistance to cytosine arabinoside in cells transfected with activated Ha-ras oncogene.

Anticancer research - 1 Jan 2000

Riva C, el Khyari S, Rustum Y, Barra Y

Abstract excerpt

The molecular basis for cancer cell resistance to 1-beta-D-arabinofuranosylcytosine (ara-C) is not well understood. Since aberrant expression and mutations of various ras oncogenes have been implicated in the poor prognosis of human cancers and in several mechanisms of drug resistance, we tested this hypothesis by determining the effect of varying level of c-Ha-ras expression and the presence of ras gene mutation...

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PMID: 7654012

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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