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Article

Two distinct molecular mechanisms underlying cytarabine resistance in human leukemic cells.

Cancer research - 1 Apr 2008

Cai Jie, Damaraju Vijaya L, Groulx Normand, Mowles Delores, Peng Yunshan, Robins Morris J, Cass Carol E, Gros Philippe

Abstract excerpt

To understand the mechanism of cellular resistance to the nucleoside analogue cytarabine (1-beta-D-arabinofuranosylcytosine, AraC), two resistant derivatives of the human leukemic line CCRF-CEM were obtained by stepwise selection in different concentrations of AraC. CEM/4xAraC cells showed low AraC resistance, whereas CEM/20xAraC cells showed high resistance. Both cell lines showed similar patterns of...

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Share to Antimetabolites, Antineoplastic
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Share to Dose-Response Relationship, Drug

Share to Drug Resistance, Neoplasm

Share to Gene Expression Regulation, Neoplastic

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Share to Precursor Cell Lymphoblastic Leukemia-Lymphoma

Source

Identifiers

PMID: 18381442
DOI: 10.1158/0008-5472.CAN-07-5528

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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