Resistance to 1-beta-D-arabinofuranosylcytosine in human T-lymphoblasts mediated by mutations within the deoxycytidine kinase gene.

Article

Resistance to 1-beta-D-arabinofuranosylcytosine in human T-lymphoblasts mediated by mutations within the deoxycytidine kinase gene.

Cancer research - 1 May 1992

Owens J K, Shewach D S, Ullman B, Mitchell B S

Abstract excerpt

We have recently identified a complementary DNA clone which encodes the complete amino acid sequence for 2'-deoxycytidine kinase (dCK), the enzyme required for the initial phosphorylation of several deoxyribonucleosides and their analogues that are widely used as chemotherapeutic and antiviral ag...

Topics

Base Sequence
Cell Division
Cytarabine
DNA
Deoxycytidine Kinase
Drug Resistance
Humans
Molecular Sequence Data
Mutation
Polymerase Chain Reaction
RNA, Messenger
T-Lymphocytes

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