Resistance to 1,25-dihydroxyvitamin D3 of a deoxycytidine kinase-deficient variant of human leukemia HL60 cells.

doi:10.1016/0014-4827(92)90061-c

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Article

Resistance to 1,25-dihydroxyvitamin D3 of a deoxycytidine kinase-deficient variant of human leukemia HL60 cells.

Experimental cell research - 1 Nov 1992

Xu H M, Kolla S S, Goldenberg N A, Studzinski G P

Abstract excerpt

A deoxycytidine kinase-deficient variant of HL60 cells (HL60-araC), isolated by its resistance to 1-beta-D-arabinofuranosyl cytosine (ara-C), shows cross-resistance to the differentiation-inducing and growth-inhibitory effects of 1,25-dihydroxyvitamin D3 (1,25(OH)2D3). This is not due to the lack of uptake of 1,25(OH)2D3 by HL60-araC cells, shown by an increased rate of intracellular accumulation of...

Topics

Biological Transport
Calcitriol
Cell Differentiation
Cell Division
Cell Survival
Clone Cells
Cytarabine
Deoxycytidine Kinase
Drug Resistance
Gene Expression
Genes, myc

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genetic Variation

Humans

Kinetics

Leukemia, Promyelocytic, Acute

Monocytes

Oligonucleotide Probes

RNA, Messenger

Source

Open in PubMed

Identifiers

PMID: 1426045
DOI: 10.1016/0014-4827(92)90061-c

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1426045-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Resistance to 1,25-dihydroxyvitamin D3 of a deoxycytidine kinase-deficient variant of human leukemia HL60 cells.PMID 1426045Read ↗

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