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Article

Resistance to 1,25-dihydroxyvitamin D3 of a deoxycytidine kinase-deficient variant of human leukemia HL60 cells.

Experimental cell research - 1 Nov 1992

Xu H M, Kolla S S, Goldenberg N A, Studzinski G P

Abstract excerpt

A deoxycytidine kinase-deficient variant of HL60 cells (HL60-araC), isolated by its resistance to 1-beta-D-arabinofuranosyl cytosine (ara-C), shows cross-resistance to the differentiation-inducing and growth-inhibitory effects of 1,25-dihydroxyvitamin D3 (1,25(OH)2D3). This is not due to the lack of uptake of 1,25(OH)2D3 by HL60-araC cells, shown by an increased rate of intracellular accumulation of...

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PMID: 1426045
DOI: 10.1016/0014-4827(92)90061-c

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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