Article
Resistance to cytosine arabinoside in acute leukemia: the significance of mutations in CTP synthetase.
Leukemia - 1 Feb 1994
Whelan J, Smith T, Phear G, Rohatiner A, Lister A, Meuth M
Abstract excerpt
The molecular events which confer cellular resistance to cytotoxic drugs such as cytosine arabinoside (ara-C) are poorly understood. Nevertheless, in a proportion of patients with acute leukemia, such events will be responsible for the failure of therapy. Mutations which cause ara-C resistance in...
Topics
- Acute Disease
- Adult
- Carbon-Nitrogen Ligases
- Cytarabine
- DNA Mutational Analysis
- Drug Resistance
- Humans
- Leukemia
- Ligases
- Mutation
- Tumor Cells, Cultured