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Article

Resistance to cytosine arabinoside in acute leukemia: the significance of mutations in CTP synthetase.

Leukemia - 1 Feb 1994

Whelan J, Smith T, Phear G, Rohatiner A, Lister A, Meuth M

Abstract excerpt

The molecular events which confer cellular resistance to cytotoxic drugs such as cytosine arabinoside (ara-C) are poorly understood. Nevertheless, in a proportion of patients with acute leukemia, such events will be responsible for the failure of therapy. Mutations which cause ara-C resistance in a chinese hamster ovary (CHO) cell model have been identified as regulatory base substitutions, occurring in specific...

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PMID: 8309250

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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