Article
Comparison of antineoplastic activity of cytosine arabinoside and 5-aza-2'-deoxycytidine against human leukemic cells of different phenotype.
Leukemia research - 1 Jan 1990
Momparler R L, Onetto-Pothier N, Momparler L F
Abstract excerpt
A comparison of the cellular and molecular pharmacology of the deoxycytidine analogues cytosine arabinoside (Ara-C) and 5-aza-2'-deoxycytidine (5-AZA-CdR) on human myeloid (HL-60), T-cell (Molt-3) and B-cell (RPMI-8392) leukemic cell lines was investigated. Ara-C was a more potent inhibitor of growth than 5-AZA-CdR. In a colony assay, 5-AZA-CdR was a more potent cytotoxic agent than Ara-C for both the myeloid and...
Topics
- Antineoplastic Agents
- Azacitidine
- Cytarabine
- DNA
- Decitabine
- Humans
- Leukemia
- Methylation
- Phenotype
- Tumor Cells, Cultured