Recovery of mitogenic activity of a growth factor mutant with a nuclear translocation sequence.

doi:10.1126/science.1699274

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Article

Recovery of mitogenic activity of a growth factor mutant with a nuclear translocation sequence.

Science (New York, N.Y.) - 28 Sept 1990

Imamura T, Engleka K, Zhan X, Tokita Y, Forough R, Roeder D, Jackson A, Maier J A, Hla T, Maciag T

Abstract excerpt

Heparin-binding growth factor-1 (HBGF-1) is an angiogenic polypeptide mitogen for mesoderm- and neuroectoderm-derived cells in vitro and remains biologically active after truncation of the amino-terminal domain (HBGF-1 alpha) of the HBGF-1 beta precursor. Polymerase chain reaction mutagenesis and...

Topics

Amino Acid Sequence
Animals
Base Sequence
Binding, Competitive
Cattle
Cell Division
Cell Line
Cell Nucleus
Cells, Cultured
DNA Replication
Endothelium, Vascular
Fibroblast Growth Factor 1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Kinetics

Mice

Mitogens

Molecular Sequence Data

Mutation

Oligonucleotide Probes

Source

Open in PubMed

Identifiers

PMID: 1699274
DOI: 10.1126/science.1699274

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-1699274-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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