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Article

Role of the juxtamembrane tyrosine in insulin receptor-mediated tyrosine phosphorylation of p60 endogenous substrates.

Endocrinology - 1 Dec 1996

Danielsen A G, Roth R A

Abstract excerpt

Prior studies have demonstrated that a juxtamembrane tyrosine (tyrosine 972) in the insulin receptor is required for the receptor to elicit various biological responses and to stimulate the tyrosine phosphorylation of two endogenous substrates, the insulin receptor substrate-1 and the adaptor pro...

Topics

Animals
CHO Cells
Cricetinae
GTPase-Activating Proteins
Insulin Receptor Substrate Proteins
Molecular Weight
Mutation
Phosphoproteins
Phosphorylation
Proteins
Receptor, Insulin
Tumor Cells, Cultured

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Tyrosine

ras GTPase-Activating Proteins

Source

Identifiers

PMID: 8940353
DOI: 10.1210/endo.137.12.8940353

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8940353-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Role of the juxtamembrane tyrosine in insulin receptor-mediated tyrosine phosphorylation of p60 endogenous substrates.PMID 8940353Read ↗

Insulin receptor substrate 1 rescues insulin action in CHO cells expressing mutant insulin receptors that lack a juxtamembrane NPXY motif.Semantic proximity Read ↗

Insulin receptor-mediated p62dok tyrosine phosphorylation at residues 362 and 398 plays distinct roles for binding GTPase-activating protein and Nck and is essential for inhibiting insulin-stimulated activation of Ras and Akt.Semantic proximity Read ↗

Cross-talk between the two divergent insulin signaling pathways is revealed by the protein kinase B (Akt)-mediated phosphorylation of adapter protein APS on serine 588.Semantic proximity Read ↗

Receptor-mediated internalization of insulin requires a 12-amino acid sequence in the juxtamembrane region of the insulin receptor beta-subunit.Semantic proximity Read ↗

Serine phosphorylation proximal to its phosphotyrosine binding domain inhibits insulin receptor substrate 1 function and promotes insulin resistance.Semantic proximity Read ↗

Structural and Biochemical Evidence for an Autoinhibitory Role for Tyrosine 984 in the Juxtamembrane Region of the Insulin ReceptorSemantic proximity Read ↗

The insulin receptor substrate IRSp53 links postsynaptic shank1 to the small G-protein cdc42.Semantic proximity Read ↗

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Insulin activation of mitogen-activated protein kinases Erk1,2 is amplified via beta-adrenergic receptor expression and requires the integrity of the Tyr350 of the receptor.Semantic proximity Read ↗

Normal insulin receptor substrate-1 phosphorylation in autophosphorylation-defective truncated insulin receptor. Evidence that phosphorylation of substrates might be sufficient for certain biological effects evoked by insulin.Semantic proximity Read ↗

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