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Article

Mutations in the Bacillus subtilis beta clamp that separate its roles in DNA replication from mismatch repair.

Journal of bacteriology - 1 Jul 2010

Dupes Nicole M, Walsh Brian W, Klocko Andrew D, Lenhart Justin S, Peterson Heather L, Gessert David A, Pavlick Cassie E, Simmons Lyle A

Abstract excerpt

The beta clamp is an essential replication sliding clamp required for processive DNA synthesis. The beta clamp is also critical for several additional aspects of DNA metabolism, including DNA mismatch repair (MMR). The dnaN5 allele of Bacillus subtilis encodes a mutant form of beta clamp containing the G73R substitution. Cells with the dnaN5 allele are temperature sensitive for growth due to a defect in DNA...

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Identifiers

PMID: 20453097
DOI: 10.1128/JB.01435-09
PMCID: PMC2897676

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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