Analysis of the contact sites on the CD4 molecule with class II MHC molecule: co-ligand versus co-receptor function.

Article

Analysis of the contact sites on the CD4 molecule with class II MHC molecule: co-ligand versus co-receptor function.

Journal of immunology (Baltimore, Md. : 1950) - 1 Jan 1997

Huang B, Yachou A, Fleury S, Hendrickson W A, Sekaly R P

Abstract excerpt

The CD4 molecule interacts with the alpha2 and beta2 domains of the MHC class II molecules. However, the class II contact sites on CD4 are less clear. Involvement of different regions throughout D1, D2, and D3 domains have been suggested. To further delineate the class II MHC contact sites on CD4...

Topics

CD4 Antigens
HLA-DR Antigens
Humans
Ligands
Mutation
Protein Binding
Protein Conformation
Receptors, Immunologic

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