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Article

Effects of transmembrane region variability on cell surface expression and allorecognition of HLA-DP3.

Human immunology - 1 Aug 2013

Crivello Pietro, Lauterbach Nina, Zito Laura, Sizzano Federico, Toffalori Cristina, Marcon Jessica, Curci Laura, Mulder Arend, Wieten Lotte, Zino Elisabetta, Voorter Christien E M, Tilanus Marcel G J, Fleischhauer Katharina

Abstract excerpt

The functional relevance of polymorphisms outside the peptide binding groove of HLA molecules is poorly understood. Here we have addressed this issue by studying HLA-DP3, a common antigen relevant for functional matching algorithms of unrelated hematopoietic stem cell transplantation (HSCT) encoded by two transmembrane (TM) region variants, DPB1(*)03:01 and DPB1(*)104:01. The two HLA-DP3 variants were found at a...

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Identifiers

PMID: 23619468
DOI: 10.1016/j.humimm.2013.04.014

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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