Article
Transforming growth factor beta1 receptor II is downregulated by E1A in adenovirus-infected cells.
Journal of virology - 1 Sept 2003
Tarakanova Vera L, Wold William S M
Abstract excerpt
Transforming growth factor beta1 (TGF-beta1) signaling is compromised in many tumors, thereby allowing the tumor to escape the growth-inhibitory and proapoptotic activities of the cytokine. Human adenoviruses interfere with a number of cellular pathways involved in cell cycle regulation and apopt...
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