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Article

Detection of beta-thalassaemia mutations using DNA heteroduplex generator molecules.

British journal of haematology - 1 Jul 1995

Savage D A, Wood N A, Bidwell J L, Fitches A, Old J M, Hui K M

Abstract excerpt

In this report we describe a rapid polymerase chain reaction (PCR) based method for the detection of beta-thalassaemia (beta-thal) mutations. This method is based on the visualization of unique DNA heteroduplex banding patterns, following non-denaturing polyacrylamide gel electrophoresis, resulting from hybridization between mutant PCR products and synthetic DNA heteroduplex generator molecules. Using the...

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Identifiers

PMID: 7646995
DOI: 10.1111/j.1365-2141.1995.tb05585.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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