Article
Detection of beta-thalassaemia mutations using DNA heteroduplex generator molecules.
British journal of haematology - 1 Jul 1995
Savage D A, Wood N A, Bidwell J L, Fitches A, Old J M, Hui K M
Abstract excerpt
In this report we describe a rapid polymerase chain reaction (PCR) based method for the detection of beta-thalassaemia (beta-thal) mutations. This method is based on the visualization of unique DNA heteroduplex banding patterns, following non-denaturing polyacrylamide gel electrophoresis, resulti...
Topics
- Base Sequence
- DNA Mutational Analysis
- Globins
- Humans
- Molecular Sequence Data
- Mutation
- Nucleic Acid Heteroduplexes
- Polymerase Chain Reaction
- Polymorphism, Genetic
- beta-Thalassemia