Article
Genetic screening and testing by induced heteroduplex formation.
Electrophoresis - 1 Jan 1996
Wood N, Bidwell J
Abstract excerpt
Clustered point mutations and small deletions or insertions within DNA are amenable to rapid analysis using induced heteroduplex formation. A single synthetic molecule (universal heteroduplex generator, UHG) may detect any of a series of such mutations following amplification by the polymerase ch...
Topics
- Anemia, Sickle Cell
- Base Sequence
- Carrier Proteins
- Cystic Fibrosis
- Electrophoresis, Polyacrylamide Gel
- Genetic Diseases, Inborn
- Genetic Testing
- Genotype
- Lectins
- Mannans
- Molecular Sequence Data
- Mutation
- Nucleic Acid Heteroduplexes
- Phenylketonurias
- von Willebrand Diseases