Applications of heteroduplex analysis for mutation detection in disease genes.

doi:10.1002/humu.1380060402

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Article

Applications of heteroduplex analysis for mutation detection in disease genes.

Human mutation - 1 Jan 1995

Glavac D, Dean M

Abstract excerpt

Double-stranded heteroduplex molecules that form between a mutant and wild-type DNA strand are often distinguished from homoduplex molecules upon gel electrophoresis. This method, heteroduplex analysis (HA), can be performed rapidly without radioisotopes or specialized equipment. Modifications an...

Topics

Cystic Fibrosis
Cystic Fibrosis Transmembrane Conductance Regulator
DNA Mutational Analysis
Genes, Viral
Genetic Testing
HIV Antigens
Histocompatibility Testing
Humans
Mutation
Nucleic Acid Heteroduplexes
Polymorphism, Single-Stranded Conformational
Sensitivity and Specificity

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