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Article

Heteropolymeric triplex-based genomic assay to detect pathogens or single-nucleotide polymorphisms in human genomic samples.

PloS one - 21 Mar 2007

Daksis Jasmine I, Erikson Glen H

Abstract excerpt

Human genomic samples are complex and are considered difficult to assay directly without denaturation or PCR amplification. We report the use of a base-specific heteropolymeric triplex, formed by native duplex genomic target and an oligonucleotide third strand probe, to assay for low copy pathogen genomes present in a sample also containing human genomic duplex DNA, or to assay human genomic duplex DNA for Single...

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PMID: 17375191
DOI: 10.1371/journal.pone.0000305
PMCID: PMC1810429

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CFTR
MTHFR

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