Article
Optimisation and properties of a UHG for genotyping of hemoglobins S and C.
Human mutation - 1 Jan 1995
Wood N, Standen G, Old J, Bidwell J
Abstract excerpt
The use of universal heteroduplex generators (UHG) as an effective means of screening for specific mutations has been previously reported. Here, we report the optimisation of a UHG system used for the rapid and simple detection of sickle cell hemoglobinopathies, HbS and HbC. The test involves het...
Topics
- Anemia, Sickle Cell
- Base Sequence
- Clinical Trials as Topic
- Exons
- Genotype
- Globins
- Hemoglobin C
- Hemoglobin, Sickle
- Humans
- Molecular Sequence Data
- Mutation
- Nucleic Acid Conformation
- Nucleic Acid Heteroduplexes