Article
Heteroduplex formation: a potential source of genotyping error from PCR products.
Prenatal diagnosis - 1 Mar 1993
Hatcher S L, Lambert Q T, Teplitz R L, Carlson J R
Abstract excerpt
The formation of heteroduplexes from polymerase chain reaction (PCR) products has recently become a diagnostic tool that is routinely used for the prenatal detection of small deletions or insertions in a number of disease-causing alleles. We present evidence illustrating that heterozygous PCR products can manifest 'invisible' heteroduplexes that can ultimately lead to genotyping errors. Justifications for these...
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