Article

Translational arrest and mRNA decay are independent activities of alphaherpesvirus virion host shutoff proteins

2024-02-02

Abstract excerpt

<h4>Summary</h4> The herpes simplex virus 1 (HSV1) virion host shutoff (vhs) protein is an endoribonuclease that regulates the translational environment of the infected cell, by inducing the degradation of host mRNA via cellular exonuclease activity. To further understand the relationship between translational shutoff and mRNA decay, we have used ectopic expression to compare HSV1 vhs (vhsH) to its homologues fro...

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Literature Corpus work: 1893e468-5248-55b3-aaf2-7228e675e8a6
DOI: 10.1101/2024.02.02.578636

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