Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Evidence for Translational Regulation by the Herpes Simplex Virus Virion Host Shutoff Protein

1 Apr 2010

Abstract excerpt

The herpes simplex virus (HSV) virion host shutoff protein (vhs) encoded by gene UL41 is an mRNA-specific RNase that triggers accelerated degradation of host and viral mRNAs in infected cells. We report here that vhs is also able to modulate reporter gene expression without greatly altering the levels of the target mRNA in transient-transfection assays conducted in HeLa cells. We monitored the effects of vhs on a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Herpesvirus Infections and Treatments
Share to RNA regulation and disease
Share to Viral Infections and Immunology Research

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 20357089
DOI: 10.1128/jvi.01819-09

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Evidence for Translational Regulation by the Herpes Simplex Virus Virion Host Shutoff ProteinPMID 20357089Read ↗

Translational arrest and mRNA decay are independent activities of alphaherpesvirus virion host shutoff proteinsSemantic proximity Read ↗

The herpes simplex virus host shutoff (vhs) RNase limits accumulation of double stranded RNA in infected cells: Evidence for accelerated decay of duplex RNASemantic proximity Read ↗

Dissecting Herpes Simplex Virus 1-Induced Host Shutoff at the RNA LevelSemantic proximity Read ↗

The virion host shutoff protein of herpes simplex virus inhibits reporter gene expression in the absence of other viral gene products.Semantic proximity Read ↗

mRNA Decay during Herpes Simplex Virus (HSV) Infections: Mutations That Affect Translation of an mRNA Influence the Sites at Which It Is Cleaved by the HSV Virion Host Shutoff (Vhs) ProteinSemantic proximity Read ↗

mRNA Decay during Herpesvirus Infections: Interaction between a Putative Viral Nuclease and a Cellular Translation FactorSemantic proximity Read ↗

The Virion Host Shutoff Endonuclease (UL41) of Herpes Simplex Virus Interacts with the Cellular Cap-Binding Complex eIF4FSemantic proximity Read ↗

Isolation of a herpes simplex virus type 1 mutant with a deletion in the virion host shutoff gene and identification of multiple forms of the vhs (UL41) polypeptide.Semantic proximity Read ↗

Role of herpes simplex virus ICP27 in the degradation of mRNA by virion host shutoff RNase.Semantic proximity Read ↗

Mutational analysis of the herpes simplex virus virion host shutoff protein: evidence that vhs functions in the absence of other viral proteins.Semantic proximity Read ↗

Herpes Simplex Virus Virion Host Shutoff Protein: Immune Evasion Mediated by a Viral RNase?Semantic proximity Read ↗

Herpes simplex virus infection stabilizes cellular IEX-1 mRNA.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.