Evidence for host-cell selection of influenza virus antigenic variants.

doi:10.1038/303706a0

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Article

Evidence for host-cell selection of influenza virus antigenic variants.

Nature - 1 Jan 2000

Schild G C, Oxford J S, de Jong J C, Webster R G

Abstract excerpt

Extensive antigenic variability and a capricious epidemiology are characteristics of influenza A and B viruses of man. The haemagglutinin (HA) undergoes frequent and progressive antigenic drift as a result of selection, under immunological pressure, of viruses possessing alterations in the amino acid sequences at specific sites in the molecule. Here we present evidence for an additional selection mechanism for...

Topics

Adolescent
Adult
Animals
Antibodies, Monoclonal
Antigens, Viral
Cell Line
Chick Embryo
Child
Child, Preschool
Dogs
Epitopes
Genetic Variation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Hemagglutination Inhibition Tests

Humans

Immunodiffusion

Influenza A virus

Kidney

Orthomyxoviridae

Source

Open in PubMed

Identifiers

PMID: 6190093
DOI: 10.1038/303706a0

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-6190093-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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