Article
Analysis of the restriction to the growth of nonegg-adapted human influenza virus in eggs.
Virology - 1 Oct 1993
Williams S P, Robertson J S
Abstract excerpt
When nonegg-adapted human influenza virus, i.e., either the natural virus present in a clinical specimen or an isolate propagated exclusively in tissue culture cells, is first passaged in the allantoic cavity of embryonated hens' eggs, variants which have amino acid substitutions around the receptor binding site are selected. We have studied the biological basis for the restriction of MDCK cell-derived virus to...
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