Sequence analysis of the haemagglutinin (HA) of influenza A (H1N1) viruses present in clinical material and comparison with the HA of laboratory-derived virus.

doi:10.1099/0022-1317-72-11-2671

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Article

Sequence analysis of the haemagglutinin (HA) of influenza A (H1N1) viruses present in clinical material and comparison with the HA of laboratory-derived virus.

The Journal of general virology - 1 Nov 1991

Robertson J S, Nicolson C, Bootman J S, Major D, Robertson E W, Wood J M

Abstract excerpt

We used the polymerase chain reaction to amplify the HA1 coding region of influenza A (H1N1) viruses present in clinical material from recent cases of influenza in the U.K. Previously, we have demonstrated that isolation of human influenza viruses in embryonated hens' eggs selects variants which have amino acid substitutions in their haemagglutinin (HA) clustering around the receptor-binding site. Such...

Topics

Amino Acid Sequence
Animals
Base Sequence
Cell Line
Chick Embryo
Cloning, Molecular
DNA, Viral
Genetic Variation
Hemagglutinin Glycoproteins, Influenza Virus
Hemagglutinins, Viral

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Influenza A Virus, H1N1 Subtype

Influenza A virus

Molecular Sequence Data

Orthomyxoviridae Infections

Polymerase Chain Reaction

Sequence Alignment

Source

Open in PubMed

Identifiers

PMID: 1940864
DOI: 10.1099/0022-1317-72-11-2671

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1940864-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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