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Article

Selection of receptor-binding variants of human influenza A and B viruses in baby hamster kidney cells.

Virology - 15 Sept 1999

Govorkova E A, Matrosovich M N, Tuzikov A B, Bovin N V, Gerdil C, Fanget B, Webster R G

Abstract excerpt

Cultivation of human influenza viruses in the allantoic cavity of embryonated chicken eggs leads to a selection of receptor-binding variants with amino acid substitutions on the globular head of the hemagglutinin (HA) molecule. Such selection can be avoided by growing the human viruses in Madin Darby canine kidney (MDCK) cells. In the present study, we tested whether baby hamster kidney (BHK) cells select...

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Identifiers

PMID: 10489338
DOI: 10.1006/viro.1999.9892

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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