Article
The putative amino-terminal signal peptide of the cloned rat brain Na(+)-Ca2+ exchanger gene (RBE-1) is not mandatory for functional expression.
The Journal of biological chemistry - 11 Aug 1995
Furman I, Cook O, Kasir J, Low W, Rahamimoff H
Abstract excerpt
The rat brain Na(+)-Ca2+ exchanger (RBE) gene, as well as other isoforms of this protein family, can be organized into 12 transmembrane alpha helices, the first of which was proposed by Durkin et al. (14) to constitute a cleavable signal peptide. We have prepared three amino-terminal mutants, in which 21, 26, and 31 amino acids beyond the initiating methionine were deleted. The deletions include the hydrophobic...
Topics
- Amino Acid Sequence
- Animals
- Base Sequence
- Biological Transport
- Brain
- Calcium
- Carrier Proteins
- Dogs
- HeLa Cells
- Humans
- Molecular Sequence Data