Article
Mammalian alpha 1-subunit of Na(+)-K(+)-ATPase does not need its amino terminus to maintain cell viability.
The American journal of physiology - 1 Aug 1994
Shanbaky N M, Pressley T A
Abstract excerpt
The amino terminus of the catalytic alpha-subunit from Na(+)-K(+)-adenosinetriphosphatase (ATPase) is not conserved among the various isoforms and species sequenced to date, yet it always includes a lysine-rich motif. To investigate the functional role played by this highly charged region, we alt...
Topics
- Amino Acid Sequence
- Animals
- Base Sequence
- Biological Transport
- Cell Line
- Cell Survival
- Chlorocebus aethiops
- Homeostasis
- Immunologic Techniques
- Ions
- Kidney
- Molecular Sequence Data
- Mutagenesis, Site-Directed
- Mutation
- Oligonucleotide Probes
- Protein Processing, Post-Translational
- Rats
- Sodium-Potassium-Exchanging ATPase