Cloning and characterization of novel human<i>SLC4A8</i>gene products encoding Na⁺-driven Cl⁻/HCO₃⁻exchanger variants NDCBE-A, -C, and -D

Abstract excerpt

The reported sequences of the human and mouse Na+-driven Cl-/HCO3(-) exchangers (NDCBEs) differ greatly in their extreme cytosolic COOH termini (Ct). In human NDCBE (NDCBE-B), a 17-amino acid (aa) sequence replaces 66 aa at the equivalent position in mouse NDCBE (NDCBE-A). We performed 5'- and 3'-rapid amplification of cDNA ends (RACE) on human brain cDNA, followed by PCR of full-length cDNAs to determine whether...

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