Article
The signal peptide of the rat corticotropin-releasing factor receptor 1 promotes receptor expression but is not essential for establishing a functional receptor.
The Biochemical journal - 1 Sept 2005
Alken Martina, Rutz Claudia, Köchl Robert, Donalies Ute, Oueslati Morad, Furkert Jens, Wietfeld Doreen, Hermosilla Ricardo, Scholz Anne, Beyermann Michael, Rosenthal Walter, Schülein Ralf
Abstract excerpt
Approximately 5-10% of the GPCRs (G-protein-coupled receptors) contain N-terminal signal peptides that are cleaved off during receptor insertion into the ER (endoplasmic reticulum) membrane by the signal peptidases of the ER. The reason as to why only a subset of GPCRs requires these additional signal peptides is not known. We have recently shown that the signal peptide of the human ET(B)-R (endothelin B...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.