Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

[Everything you ever wanted to know about ZAP-70].

Medecine sciences : M/S - 1 Feb 2005

Hivroz Claire

Abstract excerpt

The ZAP-70 tyrosine kinase has been described more than ten years ago. Its key role in thymocytes development and mature T lymphocytes activation has been illustrated by the characterization of several human immunodeficiencies presenting with mutations in the zap-70 gene resulting in the absence of ZAP-70 expression. More recently, it has been shown that deregulation of ZAP-70 activity can induce autoimmune...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Autoimmunity
Share to B-Lymphocytes
Share to Immunologic Deficiency Syndromes

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Mutation

Share to Protein-Tyrosine Kinases

Share to Signal Transduction

Share to ZAP-70 Protein-Tyrosine Kinase

Source

Identifiers

PMID: 15691485
DOI: 10.1051/medsci/2005212150

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

[Everything you ever wanted to know about ZAP-70].PMID 15691485Read ↗

ZAP-70 in Signaling, Biology, and DiseaseSemantic proximity Read ↗

Clinical, Immunological, and Genetic Features in 49 Patients With ZAP-70 Deficiency: A Systematic Review.Semantic proximity Read ↗

ZAP-70 mutation: a case with familial autoimmune haemolytic anaemia and immune deficiency.Semantic proximity Read ↗

Novel Mutation of ZAP-70-related Combined Immunodeficiency: First Case from the National Iranian Registry and Review of the Literature.Semantic proximity Read ↗

Lymphocyte Disturbance in The [Asp521Asn] ZAP70 Mutation and An Overview of All Phenotype/GenotypeSemantic proximity Read ↗

Lymphocyte disturbance and functional assessment of the [Asp521Asn] ZAP70 mutation.Semantic proximity Read ↗

The Experience of a Tertiary Reference Center in Central Anatolia with Children Carrying ZAP-70 Variants, Including Two Novel Variants.Semantic proximity Read ↗

Two patients with ZAP-70 deficiency in China present with a different genetic, immunological, and clinical phenotype.Semantic proximity Read ↗

Human severe combined immunodeficiency due to a defect in ZAP-70, a T cell tyrosine kinase.Semantic proximity Read ↗

Novel compound heterozygous mutations in ZAP70 in a Chinese patient with leaky severe combined immunodeficiency disorder.Semantic proximity Read ↗

Clinical implications of ZAP-70 expressionin chronic lymphocytic leukemia.Semantic proximity Read ↗

ZAP-70 is expressed by a subset of normal human B-lymphocytes displaying an activated phenotype.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.