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Article

ZAP-70 is expressed by a subset of normal human B-lymphocytes displaying an activated phenotype.

Leukemia - 1 Jun 2005

Nolz J C, Tschumper R C, Pittner B T, Darce J R, Kay N E, Jelinek D F

Abstract excerpt

The Syk family tyrosine kinase ZAP-70 is essential for normal T-cell development and signaling. Recently, leukemic cells from some patients with B-cell chronic lymphocytic leukemia (B-CLL) were shown to express ZAP-70. Owing to the prognostic value of B-CLL ZAP-70 expression, this phenotype may reflect intrinsic biological differences between the two subsets of disease. However, it remains unclear whether CLL-B...

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Identifiers

PMID: 15800671
DOI: 10.1038/sj.leu.2403726

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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