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Article

Structural conservation predominates over sequence variability in the crown of HIV type 1's V3 loop.

AIDS research and human retroviruses - 1 Jun 2010

Almond David, Kimura Tetsuya, Kong XiangPeng, Swetnam James, Zolla-Pazner Susan, Cardozo Timothy

Abstract excerpt

The diversity of HIV-1 is a confounding problem for vaccine design, as the human immune response appears to favor poor or strain-specific responses to any given HIV-1 virus strain. A significant portion of this diversity is manifested as sequence variability in the loops of HIV-1's surface envelope glycoprotein. Here we show that the most variable sequence positions in the third variable (V3) loop crown cluster...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to HIV Envelope Protein gp120

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Source

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Identifiers

PMID: 20560796
DOI: 10.1089/aid.2009.0254
PMCID: PMC2932551

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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