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Article

Selective modification of variable loops alters tropism and enhances immunogenicity of human immunodeficiency virus type 1 envelope.

Journal of virology - 1 Apr 2004

Yang Zhi-yong, Chakrabarti Bimal K, Xu Ling, Welcher Brent, Kong Wing-pui, Leung Kwanyee, Panet Amos, Mascola John R, Nabel Gary J

Abstract excerpt

Although the B clade of human immunodeficiency virus type 1 (HIV-1) envelopes (Env) includes five highly variable regions, each of these domains contains a subset of sequences that remain conserved. The V3 loop has been much studied for its ability to elicit neutralizing antibodies, which are often restricted to a limited number of closely related strains, likely because a large number of antigenic structures are...

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Identifiers

PMID: 15047819
DOI: 10.1128/jvi.78.8.4029-4036.2004
PMCID: PMC374252

Genes

CXCR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Click a neighbor to travelStep 1 · 12 closest

Selective modification of variable loops alters tropism and enhances immunogenicity of human immunodeficiency virus type 1 envelope.PMID 15047819Read ↗

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