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Article

The relationship between the prothrombin upstream sequence element and the G20210A polymorphism: the influence of a competitive environment for mRNA 3'-end formation.

Nucleic acids research - 1 Jan 2005

Sachchithananthan Mythily, Stasinopoulos Stan J, Wilusz Jeffrey, Medcalf Robert L

Abstract excerpt

The human prothrombin G20210A polymorphism located at the 3' cleavage site of the mRNA results in elevated plasma prothrombin levels and increased risk of venous thrombosis. This polymorphism has been shown to directly influence a variety of processes related to prothrombin mRNA metabolism. We have constructed plasmids that express the full-length prothrombin mRNA that is polyadenylated at its natural site. The A...

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Identifiers

PMID: 15718300
DOI: 10.1093/nar/gki245
PMCID: PMC549410

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The relationship between the prothrombin upstream sequence element and the G20210A polymorphism: the influence of a competitive environment for mRNA 3'-end formation.PMID 15718300Read ↗

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